Design of Experiments (DOE) is a key methodology used in Six Sigma processes and has a broad application across many disciplines including engineering, manufacturing and the sciences. It involves the design of data-gathering techniques where the experimenter is often interested in the effect of some process or intervention on some objects. In this free online course the learner is first introduced to what an experiment is and the types of variables found in experiments. The steps involved in planning DOE are then outlined and the three major approaches to using DOE in real-world settings are explained in detail. This course will be of great interest to professionals in the areas of engineering, manufacturing, Six Sigma and Quality Management who would like a greater understanding of DOE and its methodologies.